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Effects of the enkephalins on natural killer cytotoxicity

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1990 Dec;12(6):457-60.

[Effects of the enkephalins on natural killer cytotoxicity].
[Article in Chinese]
Lin J.

Source
Institute of Basic Medical Sciences, Beijing.

Abstract

Spleen mononuclear cells of BALB/C mice and YAC-1 cells were used in this experiment.

Leucine enkephalin or methionine enkephalin at time 0 was added to cell cultures and the amount of the enzyme lactate dehydrogenase released from lysed target cells was determined 22 hours after incubation. There were on average 41% (5% to 60.7%) and 63% (46.8% to 78%) enhancements of natural killer activity in the presence of leucine enkephalin (1 x 10(-11)-1 x 10(-3) mg/ml) and methionine enkephalin (1 x 10(-15)-1 x 10(-3) mg/ml) respectively. The results showed that opioid peptides can modify NK cell function.