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    IRT-101 is an active immunotherapy that works by activating a patient's immune system against infectious diseases and tumor cells
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    The purpose of TNI BioTech's immunotherapy is to increase the production of the immune system by increasing production of DC cells...
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    TNI BioTech has acquired a number of patents and is in planning on the commercialization of our patented technology.
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Company Overview

At TNI BioTech, Inc., our goal is to benefit patients with chronic and often life-threatening diseases through the activation and rebalancing of the body's immune system using our patented immunotherapy.

Our products, technologies, and patents are designed to harness the power of the immune system to improve the treatment of cancer and infections, such as HIV/AIDS and autoimmune diseases. We are currently developing active and adoptive forms of immunotherapies.

Our most advanced clinical programs involve immunotherapy with methionine-enkephalin (MENK) or low dose naltrexone, which both work by triggering opioid receptors on immune cells and lead to an activation and expansion of various cells in the immune system.

OneMedPlace Management Interview: Noreen McGurrin Griffin, CEO of TNI Biotech

IRT-101

IRT-101

 is an active immunotherapy that works by activating a patient's immune system against infectious diseases and tumor cells.

Read More

IRT-102

IRT-102 

is an adaptive immunotherapy that works by isolating and enriching a patient's own immune cells and following an enriching external incubation...

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IRT-103

IRT- 103 

is an active immunotherapy that works by activating a patient's immune system against HIV/AIDS and tumor cells.

Read More

Latest News

Low-DoseNaltrexone's Tolerability and Effects in Fatigued Patients with Parkinson's Disease: An Open-Label Study

Mar 06 2010

Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics. 2010 March 6.: 232

Abstract #13: Low-DoseNaltrexone's Tolerability and Effects in Fatigued Patients with Parkinson's Disease: An Open-Label Study
Thomas Guttuso Jr., Naomi Salins, David Lichter

Source
State University of New York at Buffalo

Introduction

One third of idiopathic Parkinson's disease (IPD) patients report fatigue as their most disabling symptom, and 58% consider fatigue to be one of their three most disabling symptoms. The use of low-dosenaltrexone (LDN), 4.5 mg qhs, has been anecdotally reported to improve fatigue in IPD.

Methods

We are examining the tolerability and effectiveness of LDN in patients with parkinsonism in an ongoing open-label trial. Fatigue and motor symptoms in the “On” state are being assessed at baseline and every 4 months over 1 year using the Parkinson Fatigue Scale (PFS-16) and the Unified Parkinson's Disease Rating Scale (UPDRS), respectively. Global Satisfaction of Treatment is also being assessed. We report here on the changes in fatigue and motor scores among the 4 IPD subjects who were fatigued at baseline, defined as a score of e 53 on the PFS-16. We also compare the fatigue changes with those from previous trials in fatigued IPD and multiple sclerosis (MS) patients.

Results

Eight subjects have been enrolled since January 2009. The 4 IPD subjects who were fatigued at baseline have experienced a mean 22% reduction in PFS-16 scores (range 13–30%) and a 15% increase in total UPDRS “On” scores after 8 months of LDN therapy. Mean Global Satisfaction of Treatment at 8 months was 8.75 on the 10-point scale. No side effects have been associated with LDN therapy among the 8 subjects. Based on previous randomized controlled trials (RCTs), the only effective therapy for fatigue in IPD has been methylphenidate, which showed a 16% decrease in fatigue from baseline. The three therapies demonstrating effectiveness in treating fatigue in MS patients in RCTs have been amantadine, modafinil, and aspirin, which decreased fatigue by 24%, 20%, and 18% from baseline, respectively. Modafinil was shown to be ineffective in treating fatigue in IPD.

Conclusions

In this small, open-label trial, LDN therapy was well tolerated and was associated with equivalent reductions in fatigue compared with historical benchmarks. These observed reductions in fatigue are unlikely to have been a function of any perceived improvements to motor symptoms, because UPDRS scores slightly worsened over the 8-month trial, as expected in this progressive disease.

Link to full article: http://www.springerlink.com/content/37300l3757706tt1/fulltext.pdf